I strongly dislike the Dvorak keyboard that seems to be so popular with the type of people who use Linux as their OS, prepare their shopping lists with LaTeX, and think [snarl]lojban[/snarl] is tolerable. The Dvorak layout is fantastically ugly, an artifact of a mind that had fair engineering skills and little or no humanity/aesthetics.
I'm working on something that would be much easier for QWERTY users to learn. My layout is optimized for right-handed Anglophones.

In English we spend a lot of our time typing THE, AND and -ING over and over again. My layout makes typing THE a quick, easy inward sweep of the right hand's strongest fingers and moves high-frequency letters such as E, T and N into the "home row." My goal is to change only 9 or 10 keys, leaving the remainder of QWERTY intact.
Here are some other alternative keyboards I found on the web:
a less-than-brilliant alphabetical layout
a more intelligent alphabetical keyboard (but what the hell did they do with the space bar?)
FrogPad (a one-hand keyboard)